Post-doctoral researcher in HILIFE University of Helsinki, Helsinki Institute of Life Science

POST-DOC­TORAL RE­SEARCHER, HILIFE


The University of Helsinki is a leading Nordic university with a strong life science research. An international academic community with a critical outlook and a creative attitude is aiming to build a better future together.

 

Helsinki Institute of Life Science, HiLIFE, is a new life science institute at the University of Helsinki established in 2017 supporting high quality research across campuses and life science faculties. HiLIFE builds on existing strengths, new recruits and partnerships to create an attractive international environment for solving grand challenges in health, food, and environment. It coordinates research infrastructures in life sciences, provides research-based interdisciplinary training and supports researchers within its units and partner faculties. In 2017 HiLIFE has a staff of 600 and a total budget of 53 M€.
HiLIFE operates mainly in the campuses of Meilahti and Viikki. In Meilahti top-notch medical research, education and care meet daily to benefit of the patients and the entire society. Meilahti is also home to the Faculty of Medicine and the Helsinki University Central Hospital (HUCH).

 

Kidney development lab located in Meilahti campus at HiLIFE is looking for outstanding candidates for a position of

Post-doctoral researcher

 

for a two to three years fixed term starting from January. There is also a possibility for continuation of the position.

 

The Academy of Finland funded project focuses on studying stem / progenitor cell biology during murine kidney development with the aim to shed light to the causes of congenital renal malformations in humans.

 

We are studying renal development to facilitate generation of new therapeutic strategies for kidney diseases. Congenital renal defects ranging from dysplasia to cancer are among the most common birth disorders, while diabetes and cardiovascular problems are major causes of renal insufficiency in adults. The genetic and developmental bases of various defects are poorly understood, and currently available treatments are limited to dialysis and organ transplantation. We are specifically interested in growth factor induced signaling in the regulation of collecting duct and nephron progenitor during their cellular events in ureteric bud branching morphogenesis and differentiation of the functional units of the kidneys, the nephrons. In vitro tissue, organ and cell culture approaches are used in combination with in vivo studies utilizing complex genetic models to facilitate comprehensive understanding of renal differentiation, which is elementary for generation of pluripotent cell-based organoid and other prospective treatment options.

 

Applicants are expected to have experience in imaging, molecular and cell biology techniques, and most importantly, show self-motivation and enthusiasm towards learning new things and technologies. Previous skills in developmental biology are acknowledged.


To apply, please submit your application as a pdf-file by October 15, 2017 using the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.

 

Applications should include a motivation letter, CV and preferably two letters of reference.

 

The application deadline October 15th 2017, preferred start time January 2018.

 

For additional information, please contact Satu.Kuure(at)helsinki.fi


Tel. +358 2941 59395
See also: http://www.biocenter.helsinki.fi/bi/Kuure/

 

Selected publications:
Kumar, A., Kopra, J., Varendi, K., Porokuokka, L.L., Panhelainen, A., Kuure, S., Marshall, P., Nevalainen, N., Härma, M-A., Vilenius, C., Lilleväli, K., Tekko, T., Mijatovic, J., Pulkkinen, N., Jakobson, M., Jakobson, M., Ola, R., Palm, E., Lindahl, M., Strömberg, I., Võikar, V., Piepponen, P.T., Saarma, M., Andressoo, JO. 2015. GDNF overexpression from the native locus reveals its role in the nigrostriatal dopaminergic system function. PLoS Genet. 17;11(12):e1005710
Akagi, T., Kuure, S., Uranishi, K., Koide, H., Costantini, F., Yokota, T. 2015. ETS-related Transcription Factors ETV4 and ETV5 are Involved in Proliferation and Induction of Differentiation-associated Genes in ES cells. J Biol Chem. Jul 29. pii: jbc.M115.675595.
Ihermann-Hella, A., Lume, M., Miinalainen, I.J., Pirttiniemi, A., Gui, Y., Peränen, J., Charron, J., Saarma, M., Costantini, F., Kuure S. 2014. Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet. 10:e1004193.
Kuure, S. 2012. Analysis of migration in primary ureteric bud epithelial cells. Book chapter in Methods in molecular biology, Kidney Development: Methods and Protocols. vol. 886: 147-55. Ed. Jon Walker & Odysse Michos.
Kuure S, Cebrian C, Machingo Q, Lu BC, Chi X, Hyink D, D'Agati V, Gurniak C, Witke W, Costantini F. 2010. Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis. PLoS Genet. 6:e1001176
Kuure, S., Chi,. X., Lu, B., Costantini, F. 2010. The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development. Development. 137:1975-1979.
Lu, B., Cebrian, C., Chi, X., Kuure, S., Kuo, R., Bates, C.M., Arber, S., Hassell, J., MacNeil, L., Schmidt-Ott, K., Barasch, J., D’Agati, V., Costantini, F. 2009. The ETS transcription factors Pea3 and Erm are required downstream of GDNF and Ret for branching morphogenesis during kidney development. Nat Genet. 41:1295-302.

 

Apply at latest 15.10.2017

 

Ap­ply link
https://rekry.helsinki.fi/sap/bc/erecruiting/posting_apply?param=cG9zdF9pbnN0X2d...

 

Due date
Sunday, October 15, 2017


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