Post-doc in Light Sheet Imaging of Synapse Development in Zebrafish Delft University of Technology, Applied Sciences Netherlands

Post-doc: Light Sheet Imaging of Synapse Development in Zebrafish

Department/faculty: Applied Sciences

Level: PhD degree

Working hours: 38 hours per week

Contract: 1 year

Salary: €2588 to €4084

Applied Sciences

The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

The Faculty of Applied Sciences has a strong programme in Imaging Physics in which new instrumentation and new methods are developed for microscopy and medical imaging. To accommodate this programme, a new research lab is being built. Most of the instruments in the lab are prototypes with unique functionalities. Once in operation, scientific and industrial users will be invited for evaluation and first scientific observations. We are looking for one post-doctoral researcher to work in this new lab.


Job description

A post-doctoral position in Imaging Physics is available at Delft University of Technology to work at the interface of optical physics and neuroscience, designing instrumentation for in vivo imaging applications.

Light sheet fluorescence imaging is a fast method to image dynamic signals in semi-transparent organisms, like larval zebrafish. We will use light sheet microscopy to investigate how synapses form in the developing zebrafish brain. The goal of the project is to design and implement a light sheet microscope based on Photo-Activation Localisation Microscopy (PALM) which will be capable of sub-diffraction-limited resolution measurements of transient intracellular signals (e.g., calcium and voltage) in single neurons. The light sheet microscope will interface with an independent light path to perform optogenetic manipulations while simultaneously imaging synaptic responses.



The successful candidate will have recently completed a PhD in biophysics, optics, or neuroscience, and have significant experimental experience with imaging and optics. Experience with fluorescence microscopy and instrumentation design is highly desirable. Programming skills in either Matlab, Labview, or Python are required. Experience with animal research is desirable.   


Conditions of employment

The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.


Information and application

For more information about this position, please contact Dr. E.C.M. Carroll, phone: +31 (0)15-2787596, e-mail: To apply, please e-mail a detailed CV along with a letter of application by 15 January 2018 to Dr. E.C.M. Carroll,

When applying for this position, please refer to vacancy number TNWIP17-060.

If you apply for this position please say you saw it on Physicaloxy


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