PhD in Microbial Protein Modification Networks Delft University of Technology, Applied Sciences Netherlands

PhD: Microbial Protein Modification Networks


Department/faculty: Applied Sciences


Level: Master degree


Working hours: 38 hours per week


Contract: 4 years


Salary: €2222 to €2840


Applied Sciences


The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.


Innovation is crucial to fulfil the potential of industrial biotechnology for sustainable production of fuels, chemicals, materials, food, and feed. Similarly, scientific and technological advances in environmental biotechnology are needed to enable novel approaches to water purification, and ‘waste-to-product’ processes, thus contributing to a circular economy. Increased fundamental knowledge encompassing enzymes, micro-organisms, and processes is essential for progress in this field.


The Department of Biotechnology covers this research area and, based on new insights, selects, designs, and tests new biobased catalysts, micro-organisms, and processes.


The Protein MS research group is a highly dynamic team located within the Cell Systems Engineering section of the Department of Biotechnology at the TU Delft. The facility will be equipped with state-of-the-art LC and high-resolution MS equipment. The group performs research on novel methods for protein characterisation, quantification, and analysis of post-translational protein modifications, with a strong focus on microbial cell systems.

 

Job description


The PhD candidate at the TU Delft will establish a proteomics platform for analysing post-translational protein modification networks in microbial cell factories. The facility will be equipped with state-of-the-art high-resolution mass spectrometry (MS) instrumentation, including the latest bioinformatics tools. Initial large-scale screening will channel into quantitative monitoring of enzymes from central metabolic pathways. Large-scale MS data will be integrated into other omics data such as metabolomics for further correlation with cell performance to determine the regulatory potential of a broad range of protein modifications in microbial cell factories. During the progress of this project, the candidate is expected to further develop methods for identification and quantification of post-translational modifications using mass spectrometry.   

  

Requirements


The protein analytics group at the TU Delft is looking for a highly motivated, technically skilled, and very ambitious PhD candidate with a strong background and experience in biotechnology, biochemistry, or a related chemical science. Preferably, the candidate also has good experience in chromatography, high-resolution mass spectrometry, and related computational approaches. The candidate must be eager to work in a multidisciplinary and dynamic setting with a focus on applied research in the field of microbial protein mass spectrometry. The position will be for a term of four years and is expected to result in a PhD. Good communication skills in English are required.

 

Conditions of employment


The TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers child care and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.


As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit http://graduateschool.tudelft.nl/ for more information.

 

Information and application


For more information about this position, please contact Martin Pabst, phone: +31 (0)15-2786369, e-mail: m.pabst@tudelft.nl. To apply, please e-mail a detailed CV along with a letter of application and 2 names of references by 31 January 2018 to Jenifer Baptiste, j.baptiste@tudelft.nl.
When applying for this position, please refer to vacancy number TNWBT17-074.


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