Post-Doctoral Fellow in Chemical Proteomics/Medicinal Chemistry University of Leuven, Laboratory of Chemical Biology Belgium




Last modified: 1/12/2017

The Laboratory of Chemical Biology at the KU Leuven works on the development of chemical tools for the study of disease relevant (intramembrane) proteases.
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Miscleavages of the Alzheimer Precursor Protein by the intramembrane protease gamma-secretase are linked to Alzheimer’s Disease. Gamma-secretase modulators (GSMs) have been developed for treatment of Alzheimer’s Disease, but failed in clinical trials. Because gamma-secretase is now also an emerging target for cancer, it is important to understand more about these type of compounds. The goal of this project, funded by the Foundation Alzheimer Research, is to understand how GSMs bind to their target. To  this end, we will apply a combination of synthetic chemistry, tandem massspectrometry-based proteomics and biochemistry. The position is available from February 1st, 2018, and application will be considered immediately until the position is filled.



  • PhD degree
  • Background in tandem mass spectrometry together with knowledge and/or practical skills in synthetic organic chemistry
  • Ambitious, motivated,creative and practically skillful
  • Experience with cellculture and biochemistry experiments is a plus


We offer a post-doctoral position for 2 years in a stimulating, interdisciplinary environment and scientific development opportunities in an international and dynamic team. You will have access to state-of-the-art research facilities.This post-doctoral position is in the framework of international mobility (see:



For more information please contact Prof. dr. Steven Verhelst, tel.: +32 16 37 45 17, mail:
You can apply for this job no later than January 31, 2018 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at

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