Postdoc in Chemical Synthesis of Bioactive Peptides and Membrane-associated Proteins University of Gothenburg, Department of Chemistry and Molecular Biology Sweden

Postdoc in Chemical Synthesis of Bioactive Peptides and Membrane-associated Proteins

 

Diary id:
 
PAR 2019/81
 
 
Employment level:
 
Time limited employment (temporary)
 
Location:
 
Department of Chemistry and Molecular Biology
 
Apply by:
 
2019-02-17
 

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

 

We are seeking a highly motivated and talented person for chemical synthesis of bioactive peptides derived from the cone snail venom as lead and perform their modifications. Neurotoxic peptides possess an enormous research potential as they are highly affine and selective against diverse therapeutically-relevant targets. Although lacking the knowledge how peptide toxins interact with membrane-associated proteins, such as ion channels or transmembrane transporters, they could significantly contribute in treatment of several diseases, e.g. cardiovascular, chronic pain, MS or even cancer. The major objective of this project is to shed light on mechanism of interaction between neuropeptides and their targets mainly focusing on chemical synthesis of interacting counterparts and peptide-mutants. This project is very interdisciplinary and combines peptide synthesis (manual and automated), organic synthesis and various purification and characterization techniques (e.g. HPLC, MS, MALDI, CD and gel electrophoresis).

 

Methods

  • Solid phase peptide synthesis

  • Liquid-phase synthesis (Organic chemistry)

  • Conjugation techniques (NCL)

  • Analytical and preparative HPLC, Mass spectrometry (ESI and MALDI TOF)

  • CD and NMR spectroscopy

  • Computational structural biology

 

The candidate will be part of a newly established Wallenberg Centre for Molecular and Translational Medicine in Gothenburg.

 

Subject area

Synthesis of biomimetic compounds

 

Specific subject description

Chemical synthesis of peptide toxins, their modification and chemical synthesis of membrane-associated proteins as interaction partners of peptide toxins

 

Job assignments

The candidate will synthesize promising toxin candidates, building blocks for modifications and develop strategies for chemical synthesis of membrane associated proteins using SPPS and conjugation techniques including purification (HPLC) and mass spectrometric characterization.

 

Eligibility

To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject. Starting date: as soon as possible or as agreed. The employment is limited (temporary) for 24 months. Full time and is placed at the Department of Chemistry and Molecular Biology.

 

Qualifications

Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. The applicant must have a PhD degree and is expected to have a strong record of scientific productivity with publications in internationally renowned journals. The applicant must have an extensive background in organic chemistry/peptide chemistry and experience in purification of peptides. Experience with handling highly hydrophobic peptides is an advantage. The successful applicant is expected to plan, execute and analyse experiments in an independent manner and to actively contribute scientifically to the group. Candidates must have excellent oral and written communication skills in English.

 

Employment

Type of employment: Fixed-term employment, 2 years 
Extent: 100 % 
Location: Department of Chemistry and Molecular Biology, Gothenburg
First day of employment: As soon as possible or as agreed

 

Appointment procedure

Please apply online

The application shall include:
Cover letter with an explanation of why you apply for the position

 

CV including scientific publications
Copy of exam certificate 
Two references (name, telephone no, relation)

 

For further information regarding the position

Regarding the position please contact: 
Alesia A. Tietze, Associate Senior Lecturer, a.tietze@tietze-lab.com
Markus Tamas, Professor, Head of Department, +46 31 786 2548, markus.tamas@cmb.gu.se

 

Regarding the appointment procedure, please contac: Ann Svensson, Human Resources Officer, +46 (0) 31-786 2558, ann.svensson@cmb.gu.se

 

Unions

Union representatives at the University of Gothenburg: http://www.gu.se/english/about_the_university/job-opportunities/union-representatives

 

How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.

 

Closing date: 2019-02-17

The University of Gothenburg promotes equal opportunities, equality and diversity.

 

Salary is determined on an individual basis.

 

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned. 


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