Assistant Professor of Xenobiotic Metabolism / Analytical Toxicology (VU University of Amsterdam Division of Molecular and Computational Toxic)

Location: AMSTERDAM FTE: 0.8 - 1 Job description A major factor in the toxicity of chemicals, and target organ toxicity, is their metabolism and transport. The (pharmaco / toxico) kinetic profiles of drugs and other xenobiotics are critically important for developing risk assessment predictions. In addition, individual variation in drug metabolism and elimination are important contributing factors to both, drug efficacy and drug safety. These principles are extremely important in animal-free approaches, where parameters such as bound/unbound chemical, uptake rate and metabolism rate are critical to develop accurate predictions of chemical hazard and safety. At the division of Molecular and Computational Toxicology, we are looking for an individual who is experienced in analytical toxicology / pharmacology who will work in collaboration with our in vitro and computational team to develop a new generation of non-animal approaches for drug and chemical safety assessment. The job will be mainly focused to chemical quantification and metabolite identification. Your duties The tenure track position is starting at the level of assistant professor in the areas of research, education and management (40:40:20), and contains amongst others the following duties: Dissemination of scientific achievements and progress in the form of scientific publications (approx. 3 per year), oral presentations at international conferences and through public engagement To acquire self-funding for research activities (consumables, equipment and scientific staff) To continuously fund, recruit and graduate PhD students To build a successful internationally reputed group in your field of expertise Educational tasks will include course coordination of, and lecturing in, relevant courses; offered by the department of Chemistry and Pharmaceutical Sciences including ADMET and Drug Disposition and Safety, Pharmacokinetics (expected up to 18 ECTS per year) You will supervise BSc and MSc student projects You are expected to participate as a member of the management team of the department and/or as a member of a committee in the department or faculty (i.e. exams committee, teaching committee, etc.) Fluency in English is mandatory and Dutch is preferred (some of the courses are in the Dutch language) Requirements Holds a PhD related to chemical analytics, metabolism or similar An established track record in toxicology / pharmacology Experienced in analytical techniques such as LC-MS, LC-MS/MS. (Experience in NMR and GC/MS is a bonus) Experience in teaching (development and coordination of courses), particularly in ADME, analytical chemistry and pharmacokinetics What are we offering? A challenging position in a socially involved organization. On full-time basis the remuneration amounts to a minimum gross monthly salary of €3,746 (scale 11) and a maximum €5,127 (scale 11), depending on your education and experience. The job profile: assistant professor is based on the university job ranking system and is vacant for at least 0.8 FTE. The appointment will be for 5 years, after which a tenured position will be offered as an assistant professor 1 , provided that the performance in the different domains (research, teaching, management) are positively evaluated by the line manager, prof. dr. Paul Jennings, and the head of the department. The progress will be monitored during the 5-year period with at least a mid-term report 2.5 years after the start of the contract and a final assessment no later than 6 months before the end. Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as: a maximum of 41 days of annual leave based on full-time employment 8% holiday allowance and 8.3% end-of-year bonus solid pension scheme (ABP), contribution to commuting expenses optional model for designing a personalized benefits package About Vrije Universiteit Amsterdam The ambition of Vrije Universiteit Amsterdam is clear: to contribute to a better world through outstanding education and ground-breaking research. We strive to be a university where personal development and commitment to society play a leading role. A university where people from different disciplines and backgrounds collaborate to achieve innovations and to generate new knowledge. Our teaching and research encompass the entire spectrum of academic endeavour – from the humanities, the social sciences and the natural sciences through to the life sciences and the medical sciences. Vrije Universiteit Amsterdam is home to more than 26,000 students. We employ over 4,600 individuals. The VU campus is easily accessible and located in the heart of Amsterdam’s Zuidas district, a truly inspiring environment for teaching and research. Diversity We are an inclusive university community. Diversity is one of our most important values. We believe that engaging in international activities and welcoming students and staff from a wide variety of backgrounds enhances the quality of our education and research. We are always looking for people who can enrich our world with their own unique perspectives and experiences. The Faculty of Science The Faculty of Science inspires researchers and students to find sustainable solutions for complex societal issues. From forest fires to big data, from obesity to medicines and from molecules to the moon: our teaching and research programmes cover the full spectrum of the natural sciences. We share knowledge and experience with leading research institutes and industries, both here in the Netherlands and abroad. Working at the Faculty of Science means working with students, PhD candidates and researchers, all with a clear focus on their field and a broad view of the world. We employ more than 1,250 staff members, and we are home to around 6,000 students. Division of Molecular and Computational Toxic The division Molecular and Computational Toxicology (moltox.chem.vu.nl) is part of the Department of Chemistry and Pharmaceutical Sciences of the Faculty of Science, and is part of the Amsterdam Institute for Molecules, Medicines and Systems (AIMMS). In the Molecular and Computational Toxicology section, research is carried out into the molecular mechanisms underlying the toxic effects of drugs and other chemicals. Using innovative cellular model systems and computational methods, the mechanism by which chemicals cause adverse effects are investigated. The section is also involved in education within the Bachelor's and/or Master's degree programs in Pharmaceutical Sciences, Medical Natural Sciences, Science Business and Innovation and Biomolecular Sciences at VU University Amsterdam, as well as the Joint Degree Chemistry (VU University and University of Amsterdam). Application Are you interested in this position? Please apply via the application button and upload your curriculum vitae and cover letter until 16 July 2020. Applications received by e-mail will not be processed. Vacancy questions If you have any questions regarding this vacancy, you may contact: Name: Prof. dr. P. Jennings Position: Professor of molecular and computational toxicology E-mail: secretariaat.sf.beta@vu.nl No agencies If you apply for this position please say you saw it on Physicaloxy

Location: AMSTERDAM

FTE: 0.8 - 1

Job description

A major factor in the toxicity of chemicals, and target organ toxicity, is their metabolism and transport. The (pharmaco / toxico) kinetic profiles of drugs and other xenobiotics are critically important for developing risk assessment predictions. In addition, individual variation in drug metabolism and elimination are important contributing factors to both, drug efficacy and drug safety. These principles are extremely important in animal-free approaches, where parameters such as bound/unbound chemical, uptake rate and metabolism rate are critical to develop accurate predictions of chemical hazard and safety. At the division of Molecular and Computational Toxicology, we are looking for an individual who is experienced in analytical toxicology / pharmacology who will work in collaboration with our in vitro and computational team to develop a new generation of non-animal approaches for drug and chemical safety assessment. The job will be mainly focused to chemical quantification and metabolite identification.

Your duties

The tenure track position is starting at the level of assistant professor in the areas of research, education and management (40:40:20), and contains amongst others the following duties:

Dissemination of scientific achievements and progress in the form of scientific publications (approx. 3 per year), oral presentations at international conferences and through public engagement
To acquire self-funding for research activities (consumables, equipment and scientific staff)
To continuously fund, recruit and graduate PhD students
To build a successful internationally reputed group in your field of expertise
Educational tasks will include course coordination of, and lecturing in, relevant courses; offered by the department of Chemistry and Pharmaceutical Sciences including ADMET and Drug Disposition and Safety, Pharmacokinetics (expected up to 18 ECTS per year)
You will supervise BSc and MSc student projects
You are expected to participate as a member of the management team of the department and/or as a member of a committee in the department or faculty (i.e. exams committee, teaching committee, etc.)
Fluency in English is mandatory and Dutch is preferred (some of the courses are in the Dutch language)

Requirements

Holds a PhD related to chemical analytics, metabolism or similar
An established track record in toxicology / pharmacology
Experienced in analytical techniques such as LC-MS, LC-MS/MS. (Experience in NMR and GC/MS is a bonus)
Experience in teaching (development and coordination of courses), particularly in ADME, analytical chemistry and pharmacokinetics

What are we offering?

A challenging position in a socially involved organization. On full-time basis the remuneration amounts to a minimum gross monthly salary of €3,746 (scale 11)
and a maximum €5,127 (scale 11), depending on your education and experience. The job profile: assistant professor is based on the university job ranking system and is vacant for at least 0.8 FTE.

The appointment will be for 5 years, after which a tenured position will be offered as an assistant professor 1 , provided that the performance in the different domains (research, teaching, management) are positively evaluated by the line manager, prof. dr. Paul Jennings, and the head of the department. The progress will be monitored during the 5-year period with at least a mid-term report 2.5 years after the start of the contract and a final assessment no later than 6 months before the end.

Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:

a maximum of 41 days of annual leave based on full-time employment
8% holiday allowance and 8.3% end-of-year bonus
solid pension scheme (ABP),
contribution to commuting expenses
optional model for designing a personalized benefits package

About Vrije Universiteit Amsterdam

The ambition of Vrije Universiteit Amsterdam is clear: to contribute to a better world through outstanding education and ground-breaking research. We strive to be a university where personal development and commitment to society play a leading role. A university where people from different disciplines and backgrounds collaborate to achieve innovations and to generate new knowledge. Our teaching and research encompass the entire spectrum of academic endeavour – from the humanities, the social sciences and the natural sciences through to the life sciences and the medical sciences.

Vrije Universiteit Amsterdam is home to more than 26,000 students. We employ over 4,600 individuals. The VU campus is easily accessible and located in the heart of Amsterdam’s Zuidas district, a truly inspiring environment for teaching and research.

Diversity

We are an inclusive university community. Diversity is one of our most important values. We believe that engaging in international activities and welcoming students and staff from a wide variety of backgrounds enhances the quality of our education and research. We are always looking for people who can enrich our world with their own unique perspectives and experiences.

The Faculty of Science

The Faculty of Science inspires researchers and students to find sustainable solutions for complex societal issues. From forest fires to big data, from obesity to medicines and from molecules to the moon: our teaching and research programmes cover the full spectrum of the natural sciences. We share knowledge and experience with leading research institutes and industries, both here in the Netherlands and abroad.

Working at the Faculty of Science means working with students, PhD candidates and researchers, all with a clear focus on their field and a broad view of the world. We employ more than 1,250 staff members, and we are home to around 6,000 students.

Division of Molecular and Computational Toxic

The division Molecular and Computational Toxicology (moltox.chem.vu.nl) is part of the Department of Chemistry and Pharmaceutical Sciences of the Faculty of Science, and is part of the Amsterdam Institute for Molecules, Medicines and Systems (AIMMS). In the Molecular and Computational Toxicology section, research is carried out into the molecular mechanisms underlying the toxic effects of drugs and other chemicals. Using innovative cellular model systems and computational methods, the mechanism by which chemicals cause adverse effects are investigated. The section is also involved in education within the Bachelor's and/or Master's degree programs in Pharmaceutical Sciences, Medical Natural Sciences, Science Business and Innovation and Biomolecular Sciences at VU University Amsterdam, as well as the Joint Degree Chemistry (VU University and University of Amsterdam).

Application

Are you interested in this position? Please apply via the application button and upload your curriculum vitae and cover letter until 16 July 2020.

Applications received by e-mail will not be processed.

Vacancy questions
If you have any questions regarding this vacancy, you may contact:

Name: Prof. dr. P. Jennings
Position: Professor of molecular and computational toxicology
E-mail: secretariaat.sf.beta@vu.nl

No agencies

If you apply for this position please say you saw it on Physicaloxy

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