PhD Candidate for Biomolecular Chemistry
Radboud University
Netherlands

PhD Candidate for Biomolecular Chemistry

  • 32 - 40 hours per week
  • Maximum gross monthly salary: € 2,972
  • Faculty of Science
  • Job level: Research University Degree
  • Duration of the contract: 4 years
  • Application deadline: 20 March 2020

 

We are looking for

 

Non-coding RNAs comprise a variety of RNA species, many of which have profound effects in the regulation of gene expression and play major roles in biological processes in health and disease. RNase MRP is composed of a 267-nucleotide non-coding RNA associated with 10 polypeptides, which functions as a ribonuclease, e.g. in ribosomal RNA maturation. The RNase MRP complex is targeted by the immune system in certain autoimmune diseases and mutations in the gene encoding the RNA component cause the genetic disease cartilage hair hypoplasia (CHH). CHH symptoms include dwarfism, immunodeficiency and predisposition to cancer. The functional characterisation of RNase MRP will not only elucidate its role in the biochemical processes involved, but will also help to explain the physical defects and symptoms associated with CHH.

As a PhD candidate, you will work on new approaches to study the biochemical functions of RNase MRP in human cells. Putative substrate RNAs identified by crosslinking-affinity purification methods will be validated and the functional consequences of CHH-associated mutations will be determined. The results of proteomics analyses will be used to build and characterise functionally relevant interaction networks. The ultimate goal is to translate these findings to the health defects observed in patients with CHH and to new strategies for treatment of this and related diseases. This research combines biochemical methods with cell and molecular biological techniques and will in part be based on large datasets generated by next-generation sequencing and mass spectrometry. You will communicate your findings via publications in peer-reviewed journals and at international conferences.

We ask

 

  • You have an MSc degree in Molecular Life Sciences, Chemical Biology, Biochemistry, Molecular Cell Biology or a related field.
  • You have a strong motivation and interest to work at an interdisciplinary research centre in a highly collaborative environment.
  • You are stress-resistant and a team player and you have an independent mind and good communication skills.
  • You have excellent skills in written and spoken English.

We are

 

As a PhD candidate, you will be part of the Biomolecular Chemistry department. Our research aligns with the Chemistry of Complex Systems research theme of the Institute for Molecules and Materials (IMM). Our laboratories are located in the Radboud Institute for Molecular Life Sciences building.

The IMM is an interdisciplinary research institute in chemistry and physics at Radboud University. IMM's mission is to perform fundamental research to understand, design and control the functioning of molecules and materials and to train the next generation of leaders in science and entrepreneurship to the highest international standards. You will have the opportunity to interact with researchers at the IMM and participate in institute-wide activities.


Radboud University

We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 22,000 students and 5,000 employees at Radboud University. And this requires even more talent and collaboration. You have a part to play!

We offer

  • Employment: 32 - 40 hours per week.
  • A maximum gross monthly salary of € 2.972 based on a 38-hour working week (salary scale P).
  • In addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus.
  • Duration of the contract: You will be appointed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years.
  • You will be able to make use of our Dual Career Service: our Dual Career Officer will assist with family-related support, such as child care, and help your partner prepare for the local labour market and with finding an occupation.
  • Are you interested in our excellent employment conditions?

Would you like more information?

For more information about this vacancy, please contact:
Ger Pruijn, Professor of Biomolecular Chemistry
Tel.: +31 24 3616847
Email: ger.pruijn@ru.nl

Apply directly

Please address your application to Ger Pruijn and submit it, using the application button, no later than 20 March 2020, 23:59 Amsterdam Time Zone.   

Your application should include the following attachments:

  • Letter of motivation.
  • CV.

 

We drafted this vacancy to find and hire our new colleague ourselves. Recruitment agencies are kindly requested to refrain from responding.


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