PhD: Computational Microscopy
Delft University of Technology Faculty Applied Sciences

PhD: Computational Microscopy

Department/faculty: Faculty Applied Sciences

Level: University Graduate

Working hours: 38.0 hours weekly

Contract: 4 years

Salary: 2325 - 2972 euros monthly (full-time basis)

Faculty Applied Sciences



The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.


The position is in the Department of Imaging Physics ( This department performs cutting-edge research spanning the range from understanding the basic principles underlying imaging technology to automated image analysis.    


The Ph.D. student will work under the guidance of Bernd Rieger and Sjoerd Stallinga who are leading a prominent international research activity in the field of optical nanoscopy. They focus especially on computational microscopy that is the intersection between the fundamentals and engineering of optical imaging systems and image processing algorithms.


Job description


Optical nanoscopy is a super-resolution microscopy technique to study subcellular structures and function via specifically targeted fluorescent labels in molecular biology. Localisation microscopy in particular offers a much better resolution (~10-50 nm) than conventional diffraction limited microscopy (~250 nm). This project aims at shifting the resolution obtainable in an optical light microscope even further towards 1 nm.


The researcher will work in a team of experimentalists and theorists who share the common goal to imaging at the nanometer scale. We aim to develop novel data-driven super-resolution reconstruction schemes by employing prior knowledge. The main objective is to reconstruct super-resolution images from incomplete data, to estimate underlying structures, to include uncertainties and symmetry restraints in the processing, to include the underlying photo-physical process in the analysis and to combine information from many chemically identical structures into one higher resolution reconstruction. This will allow to reconstruct an image which much sharper detail than present in each single image alone.




The candidate must hold a MSc. degree in Physics or Electrical Engineering with a strong background in modeling or simulation. Excellent analytical skills are essential, familiarity with group theory is expected. Experience with numerical simulations and a good programming skills are expected. Experience in the fields of image processing, light microscopy or optics is beneficial.


Conditions of employment


TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.


As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit for more information.


Information and application


For more information about this position, please contact prof.dr. Bernd Rieger, phone: +31 (0)15-2788574, e-mail: If you are interested in this position, please send the following information in English (pdf format only): 1) a letter of motivation (generic letters will be disregarded), 2) a detailed CV, 3) a BSc and MSc grade list. Please e-mail your application to Mrs. Annelies van Beek,, referring to vacancy number TNWIP19-024. The position will close on 30 May 2019.



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