PhD fellowship in Medicinal Chemistry/Radiochemistry at the Faculty of Health and Medical Sciences (University of Copenhagen Faculty of Health and Medical Sciences)

Department of Drug Design and Pharmacology is offering a three-year PhD fellowship in Medicinal Chemistry/Radiochemistry. The PhD fellowship is financed by the Danish Research Council. The fellowship is available from 15 October 2019 or as soon as possible thereafter. Project description g-Hydroxybutyric acid (GHB) is a naturally occurring compound in the mammalian brain. Already in 1982 it was reported that GHB binds with high affinity to a specific protein in the forebrain, but the molecular identity and functional relevance of this binding site has remained elusive. However, we have recently identified a GHB high-affinity target, which constitute a potential biomarker for PET imaging. The aim of this PhD project is to identify small-molecule candidates and develop suitable PET radiotracers by targeting the newly identified binding sites. Availability of such tools will enable early diagnose and optimal therapeutic intervention in implicated disease states. The tasks during this project will thus include ligand design, chemical synthesis, radiochemistry and characterization of target compounds. Principal supervisor Professor Bente Frølund, Department of Drug Design and Pharmacology E-mail: bfr@sund.ku.dk, direct phone: +45 3533 6495. Information about the Department can be found at https://drug.ku.dk/. Required qualifications As an applicant you must have: Obtained a Master´s degree in medicinal chemistry, organic chemistry, or related areas prior to the starting date Documented experience with the synthesis of small molecules Fluency in English and excellent communication skills Preferred qualifications We are looking for a highly motivated candidate with a documented strong background in organic synthesis and/or medicinal chemistry Job description Your key tasks as a PhD fellow at the Faculty are to: Carry through an independent research project under supervision Write scientific articles and the PhD thesis on the grounds of your research project Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points Obtain experience with teaching or other types of dissemination related to your PhD project Participate in the undergraduate teaching of students in pharmaceutical sciences Participate in national and international conferences and scientific meetings Stay at an external research institution, preferably abroad Key criteria for the assessment of applicants Professional qualifications relevant to the PhD project Relevant work experience Publications The grade point average achieved Other professional activities Language skills The successful applicant is also required to be enterprising and to possess good interpersonal skills Formal requirements The position is available for a 3-year period for applicants holding a relevant master´s degree. The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences. The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy. Terms of employment The position as a PhD fellow is available for a 3-year period. Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. Depending on seniority, the monthly salary begins around DKK 27,135 (approx. 3,618 EUR) (taxable) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013). Questions For further information, applicants may contact the principal supervisor, Bente Frølund, or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449 For more information on working and living in Denmark visit http://ism.ku.dk(International staff mobility) and https://www.workindenmark.dk. Application procedure The application, in English, must be submitted electronically by clicking APPLY NOW below. Your application must include: Cover letter: Letter stating the interest in and qualifications for the project (max. one page) Full CV Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used Possible publication list Other information to consider: Possible references and recommendations If you apply for this position please say you saw it on Physicaloxy

Department of Drug Design and Pharmacology is offering a three-year PhD fellowship in Medicinal Chemistry/Radiochemistry. The PhD fellowship is financed by the Danish Research Council. The fellowship is available from 15 October 2019 or as soon as possible thereafter.

Project description
g-Hydroxybutyric acid (GHB) is a naturally occurring compound in the mammalian brain. Already in 1982 it was reported that GHB binds with high affinity to a specific protein in the forebrain, but the molecular identity and functional relevance of this binding site has remained elusive. However, we have recently identified a GHB high-affinity target, which constitute a potential biomarker for PET imaging. The aim of this PhD project is to identify small-molecule candidates and develop suitable PET radiotracers by targeting the newly identified binding sites. Availability of such tools will enable early diagnose and optimal therapeutic intervention in implicated disease states.

The tasks during this project will thus include ligand design, chemical synthesis, radiochemistry and characterization of target compounds.

Principal supervisor
Professor Bente Frølund, Department of Drug Design and Pharmacology
E-mail: bfr@sund.ku.dk, direct phone: +45 3533 6495.

Information about the Department can be found at https://drug.ku.dk/.

Required qualifications
As an applicant you must have:

Obtained a Master´s degree in medicinal chemistry, organic chemistry, or related areas prior to the starting date
Documented experience with the synthesis of small molecules
Fluency in English and excellent communication skills

Preferred qualifications
We are looking for a highly motivated candidate with a documented strong background in organic synthesis and/or medicinal chemistry

Job description
Your key tasks as a PhD fellow at the Faculty are to:

Carry through an independent research project under supervision
Write scientific articles and the PhD thesis on the grounds of your research project
Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
Obtain experience with teaching or other types of dissemination related to your PhD project
Participate in the undergraduate teaching of students in pharmaceutical sciences
Participate in national and international conferences and scientific meetings
Stay at an external research institution, preferably abroad

Key criteria for the assessment of applicants

Professional qualifications relevant to the PhD project
Relevant work experience
Publications
The grade point average achieved
Other professional activities
Language skills
The successful applicant is also required to be enterprising and to possess good interpersonal skills

Formal requirements
The position is available for a 3-year period for applicants holding a relevant master´s degree.

The successful applicant will be requested to formally apply for enrolment as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD programme at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD programme at the Faculty of Health and Medical Sciences.

The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, Drug Research Academy.

Terms of employment
The position as a PhD fellow is available for a 3-year period.

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. Depending on seniority, the monthly salary begins around DKK 27,135 (approx. 3,618 EUR) (taxable) plus pension. The position is covered by the Job Structure for Academic Staff at Universities (2013).

Questions
For further information, applicants may contact the principal supervisor, Bente Frølund, or Administrator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449

For more information on working and living in Denmark visit http://ism.ku.dk(International staff mobility) and https://www.workindenmark.dk.

Application procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.

Your application must include:

Cover letter: Letter stating the interest in and qualifications for the project (max. one page)
Full CV
Diploma and transcripts of records: Master´s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used
Possible publication list
Other information to consider: Possible references and recommendations

If you apply for this position please say you saw it on Physicaloxy

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