PhD: Optical Nanoscopy at Cryogenic Temperatures Delft University of Technology Faculty Applied Sciences Netherlands

 PhD: Optical Nanoscopy at Cryogenic Temperatures


Department/faculty: Faculty Applied Sciences

Level: University Graduate

Working hours: 38.0 hours weekly

Contract: 4 years

Salary: 2325 - 2972 euros monthly (full-time basis)

Faculty Applied Sciences

 

 

The Faculty of Applied Sciences is the largest faculty of TU Delft, with around 550 scientists, a support staff of 250 and 1,800 students. The faculty conducts fundamental, application-oriented research and offers scientific education at the bachelor, master and doctoral levels. The faculty is active in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Applied Physics.

 

The position is in the Department of Imaging Physics (www.imphys.tudelft.nl). This department performs cutting-edge research spanning the range from understanding the basic principles underlying imaging technology to automated image analysis.   

 

The PhD student will work under the guidance of Bernd Rieger and Sjoerd Stallinga who are leading a prominent international research activity in the field of optical nanoscopy. They focus especially on pushing limits in light microscopy; resolving smaller and smaller structures. Their research area is computational microscopy, that is the intersection between the fundamentals and engineering of optical imaging systems and image processing algorithms.

 

Job description

 

Optical nanoscopy is a super-resolution microscopy technique to study subcellular structures and function via specifically targeted fluorescent labels in molecular biology. Localisation microscopy in particular offers a much better resolution (~10-50 nm) than conventional diffraction limited microscopy (~250 nm). This project aims at shifting the resolution obtainable in an optical light microscope even further towards 1 nm.

 

The researcher will work in a team of experimentalists and theorists who share the common goal to imaging at the nanometer scale. She/he will work as an experimentalist designing and performing experiments with cryo fluorescent microscopy. In order to achieve very high spatial resolutions from single molecule emitters in 3D will be use a so-called 4pi setup with two opposing objectives. In addition the wavefront of the light must not be disturbed by optical aberrations. In reality such aberrations are always present, but only at our targeted high resolution at cryogenic temperatures, do they play a crucial role. Therefore the candidate will incoropate adaptive optics instrumentation and algorithms to measure the wavefront distortion and subsequently correct the distortions.

 

Requirements

 

The candidate must hold a MSc degree in Physics and must have a background in experimental physics using high-end optical equipment. Experience with microscopy,  fluorescence, cryogenic and vacuum technique and/or simulation packages is beneficial but not required. 

 

Conditions of employment

 

TU Delft offers a customisable compensation package, a discount for health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. An International Children’s Centre offers childcare and an international primary school. Dual Career Services offers support to accompanying partners. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.

 

As a PhD candidate you will be enrolled in the TU Delft Graduate School. TU Delft Graduate School provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit www.tudelft.nl/phd for more information.

 

Information and application

 

For more information about this position, please contact Prof.dr. Bernd Rieger, phone: +31 (0)15 2788574, e-mail: b.rieger@tudelft.nl. If you are interested in this position, you must send the following information in English (pdf format only): 1) a letter of motivation (generic letters will be disregarded), 2) a detailed CV, 3) a BSc and MSc grade list.

 

Please e-mail your application to Mrs. Annelies van Beek, secr-qi-tnw@tudelft.nl, referring to vacancy number TNWIP19-023. The position will close on 30 May 2019.

 

Enquiries from agencies are not appreciated.


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