PhD Scholarship in Medicinal Chemistry
Monash University
Australia

PhD Scholarship - ARC Training Centre for Fragment-Based Design

Job No.: 622530

Location: Parkville campus

Employment Type: Full-time

Duration: 3-year fixed-term appointment

Remuneration: ARC scholarship awards provide a stipend of A$32,304 per annum (tax free).

About the position

The Centre for Fragment-Based Design (CFBD) is a collaboration between academic researchers at Monash University, Griffith University, and The University of Sydney that involves working closely with a range of industry partners who are developing different aspects of Fragment-Based Drug Design (FBDD). The Centre fosters close partnerships between our university and industry-based researchers to provide transformative research programs and innovative doctoral training in FBDD. A key component of this training program is that the PhD students spend a period of time working in the industry-partner laboratories.

The strategy of FBDD involves screening libraries of small chemical compounds or 'fragments' that, owing to their size, generally bind with relatively low affinity and then elaborating these to produce larger, higher affinity ligands (or hits). The process of elaboration to generate high-affinity compounds remains one of the major challenges in all FBDD programs. The goal of this PhD program is to develop high-affinity inhibitors of an essential bacterial enzyme and to characterize their antibacterial activity.

The successful applicant will be working in a multidisciplinary research team in the new ARC Training Centre for Fragment-Based Design (CFBD), where we are working with industry partners to develop new methods for small molecule discovery.

This project is in collaboration with Vernalis, who have laboratories in China and Cambridge. As part of the PhD training program the successful applicant will complete a ~12-month placement with the industry partner during their candidature.

The CFBD is supported by various industry partners including CSIRO, GE Healthcare Australia Pty Ltd, Mestrelab Research SL, Takeda California Inc., TetraGenetics Inc., VAST Bioscience Pty Ltd, Vernalis (R&D) Ltd, BioCurate Pty Ltd, FB Rice Pty Ltd, and Clarivate Analytics Ltd.

The candidate's attributes

Applications are invited from outstanding and enthusiastic graduates with a relevant background in synthetic or medicinal chemistry.

Students may be domestic or international of high scholarly calibre and will have:

  • An Honours degree, Master’s degree, or equivalent with extensive experience in chemical synthesis
  • Analytical thinking, data analysis and critical problem-solving skills
  • Excellent time management skills and ability to work independently
  • An interest in and/or experience working with industry partners
  • Applicants with publications will be highly regarded
  • Fluency in written and oral English

To apply 

Please send your application including a CV, transcripts, and cover letter and email directly to Martin.Scanlon@monash.edu

Enquiries

Informal inquiries are strongly encouraged and should be directed to the Centre Director, Professor Martin Scanlon (Martin.Scanlon@monash.edu)

Closing Date

Saturday 31 July 2021, 11:55pm AEST


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