PhD Studentship – Development of New Reagents for Protein Chemistry University of Southampton, School of Chemistry United Kingdom

PhD Studentship – Development of New Reagents for Protein Chemistry


School of Chemistry


Location: Highfield Campus


Closing Date: Sunday 01 September 2019


Reference: 1100019EB


PhD Supervisor: Dr Matthias Baud

 

Application Deadline: rolling deadline. Applications will be considered in the order that they are received, and the position closed when a suitable candidate has been identified

 

A PhD position is available to start in October 2019 for an outstanding candidate to work under the supervision of Dr Matthias Baud in the School of Chemistry at the University of Southampton. This project will be at the interface of the chemical and biological sciences, and will combine state-of-the-art synthetic organic chemistry with biochemical, analytical and biophysical methods. The successful candidate will focus on the development of novel biocompatible reagents and methodologies for the controlled chemical modification of proteins, and exploit these reagents to study the properties and function of key protein post-translational modifications (PTMs) using biochemical/biophysical assays. We are particularly interested in a range of PTMs resulting from cellular oxidative stress, which are currently impossible to study using conventional methodologies. On the longer term, the new reagents and methods will unlock exciting opportunities for studying the so far elusive function of these PTMs in human biology, with potential implications in drug discovery and the treatment of diseases resulting from unregulated cellular redox events. Relevant literature can be found below:

 

Chem. Rev. 2015, 115, 2174-2195

Chem. Rev. 2013, 113, 4633-4679

Chem. Soc. Rev. 2018, 47, 231-268

J. Chem. Inf. Model. 2017, 57, 3124-3137

 

The successful candidate will join the Baud group in the modern synthetic chemistry laboratories in the School of Chemistry at the University of Southampton, which benefits from excellent MS, NMR and X-ray facilities, each supported by dedicated specialist staff. Excellent knowledge and experimental skills in synthetic organic chemistry will be essential, as this will constitute a key part of the project. The multidisciplinary nature of this project will also give the opportunity to the student to acquire knowledge and skills in other relevant disciplines both in our group and with our collaborators. Those include biophysical techniques (e.g. DSF, NMR, ITC, FP, SPR, MST), biochemistry (e.g. protein expression/purification), and structural techniques (e.g. computational modelling, X-ray crystallography). The candidate will also have opportunities to develop supervisory, written and oral communication skills, excellent preparation for a career in academia or industry.

 

The project is funded for 3 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in organic chemistry or allied subjects/relevant disciplines. Funding will cover fees and a stipend at current research council rates (201819 rates were £14,777 and should increase for 201920).

 

Due to funding restrictions this position is only open to UK students and EU students who meet the RCUK eligibility criteria

 

Applications for a PhD in Chemistry should be submitted online at https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Search

 

Please ensure you select the academic session 2019-2020 in the academic year field and click on the Research radio button. Enter Chemistry in the search text field.

 

Please place Matthias Baud in the field for proposed supervisor/project

 

General enquiries should be made to m.baud@soton.ac.uk. Any queries on the application process should be made to feps-pgr-apply@soton.ac.uk

 

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified


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