Ph.D.Position in in Physics and Chemistry
University of Oldenburg - Faculty of Mathematics and Science, Institute of Physics
Germany

The German Research Foundation (DFG) -founded Research Training Group 1885 Molecular Basis of Sensory Biology is offering a


Ph.D. position (TV-L E13 65%) m / f / d
Theoretical and computational methods for sensory biology


at the Carl von Ossietzky University of Oldenburg. The position starts on January 01 st , 2020 and is funded for 3 years.


The overall goal of this research project is to advance computational modeling techniques as well as molecular dynamics (MD) or free energy perturbation approaches to permit computational studies of biological macromolecules and molecular assemblies that are central to the molecular basis of many sensory processes (including vision , hearing, magnetoreception). For more information please visit www.quantbiolab.com .


At present, various biomolecular mechanisms can be studied using advanced computational modeling techniques, which model the motion of every atom in a biomolecular system and the forces acting between them. This elaborate approach to the fundamental laws of nature, as well as Newton's Laws of Motion, and provides a glimpse of biomolecular mechanisms at the smallest level of detail ?? down to the individual atoms ?? which is otherwise possible through experimental techniques. Much of the complexity of biomolecular systems is computationally intensive, but with the emergence of millions of atoms in the future. Even with the powerful supercomputers available today, however, The computational complexity still severely limits the range of processes that can be studied directly using all-atom MD simulations: large conformational changes in proteins often take place on the course of milliseconds and are therefore too slow to be observed during a simulation. Events that do occur, but are rare, will often be viewed with too poor statistics to draw solid conclusions. Furthermore, it is quantitatively in a way suitable for comparison with experimental findings. will often be considered with too poor statistics to draw solid conclusions. Furthermore, it is quantitatively in a way suitable for comparison with experimental findings. will often be considered with too poor statistics to draw solid conclusions. Furthermore, it is quantitatively in a way suitable for comparison with experimental findings.


This project aims to develop ULTRO (Universal Tool for Modeling Biophysical Processes) ?? A unique methodology based on MD simulations, tailored to study a range of mechanical processes in biomolecular structures, which are also slow to be considered in traditional MD simulations. To achieve the goal, ULTRO wants to use a modified MD algorithm that is designed to determine the free energy profile along a specific reaction coordinate. As such, ULTRO wants to provide a hypothesis-driven rather than exploratory approach: a specific process wants to be tested rather than letting the system move freely to "see what happens".


We are looking for a highly motivated PhD candidate with an academic degree (Master or equivalent) in Physics, Chemistry or related fields. Applicants should have good computing skills, experience and training in computational modeling and a strong interest in computational biophysics. Experience with classical MD simulation and free energy perturbation methods is an advantage. Good English language skills are expected.


The University of Oldenburg is dedicated to increasing the percentage of employees in the field of science. Therefore, women are strongly encouraged to apply. According to § 21, 3 NHG female applicants are preferred in case of equal qualification. Applicants with disabilities wants to be preferred in case of equal qualification.


Your application should include a letter of motivation, a detailed CV, a publication list, at least two personal references (including phone numbers), university and high school certificates. Please send your application preferentially by email as a single pdf-file to Prof. Dr. med. Ilia Solov ?? yov ( ilia@quantbiolab.com ), Carl von Ossietzky University, Faculty V, Faculty of Mathematics and Science, Institute of Physics, 26111 Oldenburg.


All applications received before the 01 st of November 2019 will be considered. We want to start looking at the applications after the deadline.


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