Postdoctoral Researcher in Cryo-EM
University of Zurich Department of Chemistry

Department of Chemistry
Department of Biochemistry

Postdoctoral researcher in cryo-EM
70 %

The research groups of Prof. Amedeo Caflisch (Department of Biochemistry) and Prof. Cristina Nevado (Department of Chemistry) at the University of Zurich are looking for a post-doctoral associate with strong experience in cryo-electron microscopy and single-particle analysis.

The researcher is expected to contribute expertise in single-particle cryo-EM to support ongoing collaborative projects aiming at the optimization and characterization of in-house designed proteolysis targeting chimeric (PROTAC) molecules that show nanomolar affinity on cancer-relevant targets. On a second stage, the postdoctoral researcher will have the possibility to manage her/his own independent research project within the main research focus areas of the host laboratory. The researcher will have access to the Center for Microscopy and Image Analysis in the same building on campus. Please find more information on the center here.

Your responsibilities

The activities of this position involve mainly:
  • Protein expression (mainly in E. coli) and purification
  • Cryo-EM sample handling and preparation protocols including negative staining and sample vitrification
  • Process single particle cryo-EM data including handling raw data, interpretation, 3D reconstruction and map refinement, and model building
  • Structure-based optimization of small-molecule ligands and PROTACs

Your profile

Experience on data-processing and structure solution of small size protein complexes (<150 kDa)is desired. The candidate should be about to receive their PhD degree or have less than three years of previous post-doctoral experience. Applications from senior researchers will not be considered.

What we offer

Our well-funded drug discovery research program combines inspiring international research environment with access to state-of-the-art scientific infrastructure. Our alumni value their comprehensive training: about 25% of them are offered a tenure track assistant professorship position, with the vast majority of the rest finding employment in large pharma or biotech industry.

Place of work

Winterthurerstrasse 190, 8057 Zurich

Start of employment

Starting date: by arrangement (immediate entry possible).
Length: 3 years with an initial 1-year contract.

Applications are to be submitted as a single PDF file and must contain a cover letter, a concise summary of past accomplishments in cryo-EM, a CV (resumé of maximum two pages), and at least one letter of support or the names and contact details of two (former) advisors.

Further information

Prof. Dr. Amedeo Caflisch

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