Research Associate in Chemical Biology
Imperial College London Department of Chemistry
United Kingdom

Job summary

We are seeking an outstanding Research Associate in Chemical Biology to contribute to an EPSRC funded project in the Barnard group in the Department of Chemistry based on the development of novel chemical probes for intracellular protein-protein interactions, in collaboration with the lab of Professor Ed Tate in the Department of Chemistry.

Job listing information

  • Reference NAT00777
  • Date posted 15 October 2020
  • Closing date 13 November 2020

Key information about the role

  • Location White City Campus (map)
  • Position type Full time, fixed term
  • Salary £40,215 – £47,579 plus benefits
  • Department Department of Chemistry
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We are seeking an outstanding Research Associate in Chemical Biology to contribute to an EPSRC funded project in the Barnard group in the Department of Chemistry based on the development of novel chemical probes for intracellular protein-protein interactions, in collaboration with the lab of Professor Ed Tate in the Department of Chemistry.

Duties and responsibilities

This project will involve the development of helix mimetic probes targeting therapeutically relevant protein-protein interactions and the establishment of reliable assays for the characterisation of their cellular protein binding profile using chemoproteomics techniques. The helix mimetic probes will be based on previously published scaffolds by ourselves (Angew. Chem. Int. Ed. 2015 54, 2960. Org. Lett. 2019, 21, 4433) and others. The successful candidate will be expected to take a leading role in probe design and synthesis and the characterisation of their cellular target profile using similar approaches to those published by the Tate group (J. Am. Chem. Soc. 2020, 142, 12020. ACS Chem. Biol. 2020, 15, 2, 325.) alongside coordinating collaborative aspects of the project.

Essential requirements

You will have a PhD in chemical biology or organic chemistry, or a closely related field, or an equivalent level of professional qualifications and experience, with a strong desire to progress in your career at a world leading research institution.

Essential criteria include a strong track record in chemical biology, preferably demonstrated by first author publications in leading research journals, experience in multi-step organic synthesis and small molecule characterisation, creativity and the ability to work effectively in an efficient and independent manner and achieve clear objectives within a multidisciplinary team.

Additional training and support can be provided on key techniques where necessary. Prior experience in any of the following would be highly advantageous: cell culture, molecular biology or mass spectrometry based chemoproteomics.

Further information

The project is funded for a period of two years, with a possible one-year extension. The start date is from 1st February 2021 with some flexibility to start later.

We particularly encourage applications from women and underrepresented ethnic minority groups.

Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £35,477- £38,566 per annum.

Interview date: 30 November 2020

Informal enquiries to Dr Anna Barnard: a.barnard@imperial.ac.uk,

http://www.imperial.ac.uk/the-barnard-group/

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research


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