Research Associate in Chemistry
Imperial College London Department of Chemistry
United Kingdom

Job summary

The Di Antonio research group is looking for a talented Research Associate to join the team studying Nucleic Acids structures, working at the interface between Chemistry and Biology. You will work in a multidisciplinary team based in the new Imperial College Molecular Science Research Hub in White City Campus and in close collaboration with the satellite research group that we have recently established at the Francis Crick Institute. This...

Job listing information

  • Reference NAT00899
  • Date posted 29 March 2021
  • Closing date 25 April 2021

Key information about the role

  • Location White City Campus (map)
  • Position type Full time, fixed term
  • Salary £40,858 – £48,340 plus benefits
  • Department Department of Chemistry
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

The Di Antonio research group is looking for a talented Research Associate to join the team studying Nucleic Acids structures, working at the interface between Chemistry and Biology. You will work in a multidisciplinary team based in the new Imperial College Molecular Science Research Hub in White City Campus and in close collaboration with the satellite research group that we have recently established at the Francis Crick Institute.

This position is aimed to outstanding scientists wishing to develop novel chemical biology tools to interrogate DNA structural dynamics in cells, with particular interest in probing epigenetic changes associated with ageing. You will be working in a highly multidisciplinary team and contribute to the research ongoing in the group developing a range of experimental approaches at both the chemical and biological level.  

Duties and responsibilities

You will develop and implement chemical biology tools to target and visualise individual structural and chemical DNA features, combining chemical probes with biological tools such as CRISPR-Cas9. You are expected to contribute to the development of these tools from a synthetic chemistry point of view as well as from a more molecular-biology and cell-biology angle, although previous experience in all these areas is not expected.

As a member of the Di Antonio group, you will also be collaborating with other group members and have the opportunity to support with student supervision. You will also have the opportunity to present your work at international conferences or webinars and leverage on the recently established group satellite at the Crick Institute to engage with the wider biomedical community for application of the platform developed.  

Essential requirements

Applicants are expected to have a PhD in Chemical Biology, Molecular Biology, Biochemistry, Medicinal Chemistry, or a closely related area, or equivalent multidisciplinary experience.

Although the nature of the research is highly multidisciplinary, some experience in synthetic organic chemistry is essential to efficiently prepare chemical probes required. Previous experience in Nucleic Acids research both at the chemistry and biochemistry level will be beneficial but not essential. Similarly, experience with molecular biology and/or CRISPR-Cas9 technologies will be considered highly beneficial but not essential.

The successful candidate must be able to work independently and demonstrate strong organisational and multidisciplinary research collaboration skills. This is an ideal position for experienced scientists seeking to develop innovative Chemical-Biology tools, and with the ambition to establish an independent group in this area. Appropriate support will be provided to successful candidates to develop competitive fellowship applications.

Further information

The post will be based at the state-of-the-art £170M Molecular Sciences Research Hub at Imperial College White City campus. Appointment will be on a Fixed Term Contract of 1 Year in the first instance but has the potential to continue further, providing further funding is ensured by the PI or successful fellowship applications of the candidates.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 - £39,183 per annum.

Informal enquiries are welcome and can be made to Dr Marco Di Antonio (m.di-antonio@imperial.ac.uk). Please note that this email address is for enquiries only and you should not send your application to this email. CV and covering letter should be submitted via the online application.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes which are ultimately aimed towards finding new treatments and making scientific and medical advances, and where there are no satisfactory or reasonably practical alternatives to their use. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research


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