Research Associate in Medicinal Chemistry and Cancer Drug Discovery
Imperial College London Department of Chemistry
United Kingdom

Job summary

We are seeking an outstanding medicinal chemist to lead a collaborative drug discovery project on a novel anticancer drug target, in the group of Prof Ed Tate at Imperial College. The post will be based at the state-of-the art £170M Molecular Sciences Research Hub at Imperial’s new White City Campus, in collaboration with scientists at the University of Oxford, and is available full time from May/June 2021 (or as soon as possible thereafter).

Job listing information

  • Reference NAT00885
  • Date posted 19 March 2021
  • Closing date 9 April 2021

Key information about the role

  • Location White City Campus (map)
  • Position type Full time, fixed term
  • Salary £40,858 – £48,340 plus benefits
  • Department Department of Chemistry
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We are seeking an outstanding medicinal chemist to lead a collaborative drug discovery project on a novel anticancer drug target, in the group of Prof Ed Tate at Imperial College.

The post will be based at the state-of-the art £170M Molecular Sciences Research Hub at Imperial’s new White City Campus, in collaboration with scientists at the University of Oxford, and is available full time from May/June 2021 (or as soon as possible thereafter).

Duties and responsibilities

You will lead the medicinal chemistry programme and join a team of researchers to apply cutting edge structure-guided drug discovery against a challenging multi-pass transmembrane enzyme upstream of critical signalling pathways in the tumour microenvironment. We have extensive expertise on this target, with a complete suite of powerful assays from target to cell models and beyond, a unique structural biology platform enabling structure-guided design for the first time against this target, and multiple novel validated inhibitor series from high-throughput screening. We have assembled a team of outstanding scientists including medicinal chemists, experts in cell and molecular biology, and structural biology, positioning the programme for hit-to-lead and target validation in cell models and in vivo. Further details will be discussed in confidence with shortlisted candidates.

Essential requirements

    • Hold a PhD in medicinal chemistry, chemical biology or a closely related field; or an equivalent level of professional qualifications and experience
    • Strong research track record relative to experience, in academia and/or industry
    • Experience in synthetic medicinal chemistry
    • Experience in targeted drug design and structure-activity relationship analysis
    • Independent capability and creativity in hypothesis generation and experimental design
    • Ability to mentor junior researchers, and to set and attain research objectives as part of a multidisciplinary team

Desirable criteria include experience in optimisation of pharmacokinetics and physicochemical properties, molecular modelling, chemoinformatics and in silico drug design, and direct experience in cancer drug discovery.

Further information

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 - £39,183 per annum.

The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel.

For informal enquiries about the post, please contact Professor Ed Tate: e.tate@imperial.ac.uk

(http://www.imperial.ac.uk/tate-group/).  

If you have any queries, please contact Nayrin Noori, Senior HR Administrator: n.noori@imperial.ac.uk.  

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research


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